Concepedia

Publication | Closed Access

Rifampicin and vitamin D metabolism

DOI

102

Citations

0

References

1980

Year

M J Brodie, Alan R. Boobis, C. T. Dollery, Carmel J. Hillyard, D J Brown, I. Maclntyre, B K Park
Clinical Pharmacology & Therapeutics

Abstract

A 2-wk course of rifampicin orally (600 mg/day) in 8 male subjects resulted in a consistent fall in plasma 25-hydroxycholecalciferol (25-OHD) levels of around 70%, accompanied by increased oxidation of antipyrine and 6 beta-hydroxycortisol (indicative of hepatic enzyme induction). Plasma levels of 1,25-dihydroxycholecalciferol, parathyroid hormone, and calcitonin were not altered. The fall in 25-OHD may represent the earliest lesion of drug-induced osteomalacia.