Brain oxytocin receptors mediate ejaculation elicited by 7‐hydroxy‐2‐(di‐<i>N</i>‐propylamino) tetralin (7‐OH‐DPAT) in anaesthetized rats

Abstract

Brain oxytocin receptors mediate male sexual responses elicited by i.c.v. 7-OH-DPAT in anaesthetized rats whereas L6 spinal oxytocin receptors only impair the occurrence of ejaculation. Peripheral oxytocin receptors are marginally involved in 7-OH-DPAT-induced sexual responses. These findings should be considered for the development of potential pharmacological treatment of premature ejaculation in man.