Non-Steroidal Anti-Inflammatory Drugs Increase the Antiretroviral Activity of Nucleoside Reverse Transcriptase Inhibitors in HIV Type-1-Infected T-Lymphocytes: Role of Multidrug Resistance Protein 4

Abstract

NSAIDs can improve the antiretroviral activity of NRTIs, increasing their intracellular concentration by blocking MRP4. This finding could have implications for success of antiviral therapy.