International Experience with NORPLANT and NORPLANT-2 Contraceptives

TLDR

The study analyzes medical events that led to discontinuation of NORPLANT and NORPLANT‑2 contraceptives using data from four large datasets. The authors review over 20,000 woman‑years of NORPLANT capsule use and 6,000 woman‑years of NORPLANT‑2 rod trials, analyzing medical events that caused discontinuation. Implant contraception shows low pregnancy rates and high continuation rates over five years, with women under 50 kg experiencing cumulative five‑year pregnancy rates below 1 per 100 versus an overall rate of 3.5 per 100.

Abstract

Experience encompassing more than 20,000 woman-years of use of NORPLANT capsules and 6,000 woman-years of trials of NORPLANT-2 rods is reviewed. Implant contraception repeatedly has been associated with low pregnancy rates and high continuation rates through five full years of use. Weight has proved to be a factor related to effectiveness. Women weighing less than 50 kg experienced cumulative five-year pregnancy rates well below 1 per 100, whereas the overall cumulative rate has been 3.5 per 100. Medical events reported during use that have led to discontinuation are analyzed from four large data sets.Experience encompassing more than 20,000 woman-years of use of NORPLANT capsules and 6000 woman-years of trials of NORPLANT-2 rods is reviewed. Implant contraception repeatedly has been associated with low pregnancy rates and high continuation rates through 5 years of use. Weight has proved to be a factor related to effectiveness. Women weighing less than 50 kg experienced cumulative 5-year pregnancy rates well below 1 per 100, whereas the overall cumulative rate has been 3.5 per 100. Analysis is provided of medical events that have led to discontinuation, based on 4 large data sets.