Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties

Abstract

Our data suggest that amino and phosphate surface modifications, but not polyethylene glycol (PEG), mitigate the proinflammatory and immunomodulatory effect of SiO₂ NPs in allergic airway inflammation, paving the way for new strategies in the production of nanomaterials with lower health impact for humans.