Case of Toxoplasma Polymyositis

Abstract

BitfsH days for one to two weeks; they noted no toxicity.Sutton (1938) also remarked on its lack of toxicity when used as a local application.However, Slotkowski (1957) reported the case of a child who developed ulceration of his oral mucosa as a result of excessive crystal violet treatment.He remarked on the need to be aware of this possible complication of treatment and suggested that it might previously have been mistaken for a result of the candidial infection.At other sites crystal violet is well recognized as a potential irritant.When vaginal candidiasis is treated with local applica- tions of crystal violet some patients have to discontinue treatment because of its irritant effects (Jennison and Llywelyn-Jones, 1957).If the dye is in accidental contact with the conjunctival epithelium it will cause oedema, hyperaemia, and necrosis of the epithelium within a few hours (Hosford and Smith, 1952).When taken orally as a vermifuge, crystal violet may cause diarrhoea, nausea, and vomiting, suggesting a local effect on the gastrointestinal mucosa (Beckman, 1961 ; Martin- dale, 1967).It might therefore be expected that similar reactions could occur when crystal violet is applied to the oral mucosa.It seems likely that many oral mucosal reactions to crystal violet have gone unrecognized, and it is clear that if crystal violet is used it should be limited to a maximum course of three days with twice-daily applications.As nystatin suspension now provides a satisfactory method of treating oral candidiasis, there would seem to be a substantial case for the abandonment of local crystal violet applications to the oral mucosa.It might be that many sore mouths associated with thrush would dis appear along with the crystal violet.