Plasma from patients with cirrhosis increases tissue plasminogen activator release from vascular endothelial cells <i>in vitro</i>

Abstract

Our results indicate that factors in plasma from patients with decompensated cirrhosis directly stimulate t-PA release from the vascular endothelial cells, while any increased PAI-1 release observed in comparable in vivo situations is probably an indirect response to an increase of t-PA or a result of impaired hepatic clearance.