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The facile synthesis of a large ring lactone by acid-catalysed cyclisation of an (z)-ene-diyne hydroxy acid precursor.

EngineeringHydroxy Acid PrecursorFacile SynthesisOrganic ChemistryAcid-catalysed CyclisationCatalysisChemistryAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering