Studies on Synthetic Nucleosides, II. Novel Synthesis of Pyrimidine Glucosides.

Abstract

A new synthetic method is developed for the synthesis of pyrimidine glucosides by the fusion of trimethylsilylpyrimidines and α-acetobromoglucose followed by mild alkaline treatment. 1-β-D-Glucopyranosyl-uracil, -thymine, and-cytosine (picrate) were obtained in good yields. The physical constants of thus obtained nucleosides and their acetyl derivatives show good agreement with those of reported nucleosides.