TREATMENT WITH EITHER ANTI-CD4 OR ANTI-CD8 MONOCLONAL ANTIBODIES BLOCKS ???? T CELL-MEDIATED REJECTION OF INTESTINAL ALLOGRAFTS IN MICE

Abstract

These data demonstrate that rejection of intestinal allografts in the murine model was absolutely dependent on alphabeta but not gammadelta T cells. Furthermore, both CD4+ and CD8+ T cells were necessary for small bowel allograft rejection. Additional studies will be required to determine whether the effects of monoclonal antibody treatment were due solely to depletion of T cells or were mediated at least in part through an active process that altered the functional properties of the targeted T cell subset.