ENTROPY STRUCTURE OF A CROSS-DIFFUSION TUMOR-GROWTH MODEL

Abstract

The mechanical tumor-growth model of Jackson and Byrne is analyzed. The model consists of nonlinear parabolic cross-diffusion equations in one space dimension for the volume fractions of the tumor cells and the extracellular matrix (ECM). It describes tumor encapsulation influenced by a cell-induced pressure coefficient. The global-in-time existence of bounded weak solutions to the initial-boundary-value problem is proved when the cell-induced pressure coefficient is smaller than a certain explicit critical value. Moreover, when the production rates vanish, the volume fractions converge exponentially fast to the homogeneous steady state. The proofs are based on the existence of entropy variables, which allows for a proof of the non-negativity and boundedness of the volume fractions, and of an entropy functional, which yields gradient estimates and provides a new thermodynamic structure. Numerical experiments using the entropy formulation of the model indicate that the solutions exist globally in time also for cell-induced pressure coefficients larger than the critical value. For such coefficients, a peak in the ECM volume fraction forms and the entropy production density can be locally negative.