Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents

Abstract

Coordinated inhibition of hypothalamic orexinergic and locus coeruleus noradrenergic neurons is not required for anesthetic induction. Normal emergence from halothane-induced hypnosis in orexin-deficient mice suggests that additional wake-promoting systems likely remain active during general anesthesia produced by halothane.