Antibiotic resistance patterns of uropathogens isolated from catheterized and noncatheterized patients in Dhaka, Bangladesh

Abstract

Catheter-associated urinary tract infection (CAUTI) is the most common device-associated nosocomial infection worldwide. Bacteria, which exist as a biofilm inside catheters, show higher antimicrobial resistance when compared to non-CAUTI pathogens. The present study was conducted to determine the antibiotic susceptibility patterns of CAUTI and non-CAUTI bacteria. The antibiotic susceptibility patterns of 102 uropathogens from noncatheterized patients and 100 uropathogens from catheterized patients were compared using the disc diffusion method. A higher incidence of uropathogens was correlated with catheter use in male patients. Escherichia coli was the predominant isolate obtained from catheterized (81%) and noncatheterized (67%) patients. This was followed by Pseudomonas aeruginosa, with rates of 28% and 15% in non-CAUTI and CAUTI patients, respectively. Overall, the E. coli isolates from CAUTI patients showed significantly higher resistance (p < 0.05) than those from non-CAUTI patients against all antibiotics tested, except for trimethoprim/sulfamethoxazole and gentamicin. Catheter-associated P. aeruginosa isolates showed significantly higher resistance (p < 0.05) against most antibiotics tested compared to non-catheter-associated isolates. Uropathogens from CAUTI patients exhibit significantly higher resistance to most antibiotics than non-CAUTI isolates. This is an important factor to take into consideration when choosing correct treatment options for patients with urinary tract infection.