Journal of the Chemical Society Chemical Communications · 1974 · 21 citations · 0 references
Life SciencesBiochemistryChemistryCatalysisEnzyme MechanismEnzymologyEnzyme KineticsSurfactantsEnzyme Kinetic Isotope EffectsGeneral Acid-base CatalysisGeneral Base CatalysisHistidine CatalysisHydrolysisHydrolysis Reaction MechanismNucleophilic CatalysisSolvent Kinetic Isotope Effect
Micelles of the functional surfactant (II) derived from histidine catalyse the hydrolysis of diphenyl p-nitrophenyl phosphate; deuterium kinetic solvent isotope effects, k(H2O)/k(D2O)ca. 2·5, suggest that (II) acts as a general base rather than as a nucleophilic catalyst.