Hemoglobin · 2001 · 37 citations · 1 references
Life SciencesGeneticsHematologyGenetic CounselingHuman GeneticsPrenatal DiagnosisAnemiaGenetic DisordersPrenatal Diagnosis Of HemoglobinopathiesPrenatal Genetic CounselingPrenatal Genetic DiagnosisPrenatal Molecular TestingBeta Thalassemia Prenatal DiagnosisCarrier ScreeningCarrier Screening In PregnancyHemoglobinopathy ScreeningMolecular Diagnosis Of HemoglobinopathiesMolecular Prenatal DiagnosisPrenatal Counseling For HemoglobinopathiesThalassemia Major
The use of modern DNA techniques enabled us to characterize and identify 44 distinct beta-thal mutations and nine alpha-thal genotypes in the UAE population. All of the beta-thal mutations were severe beta+ or beta0 types resulting in transfusion-dependent phenotypes. Furthermore, a large number of alphaT alleles in the alpha-thal carriers and in patients with Hb H disease, accentuate the importance of Hb H disease as a public health problem. The overall data presented here will be useful for genetic counseling, pre-marital carrier screening and the establishment of a comprehensive prenatal diagnosis program.
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CONSANGUINEOUS MARRIAGES IN THE UNITED ARAB EMIRATES
L. I. AL-GAZALI, Abdulbari Bener, Yousef M. Abdulrazzaq et al. · Journal of Biosocial Science · 1997 · 250 citations