Nano Letters · 2011 · 101 citations · 23 references
EngineeringBioengineeringBiomedical EngineeringBiomedical ImagingBiomedical OpticsNanomaterialsCancer NanomedicineCellular ImagingNanomedicineOptical Coherence TomographyOptical ImagingSentinel Lymph Node ImagingGold NanostructuresHigh-resolution ImagingNanocarrier Uptake KineticsNanoparticle Imaging AgentsNanoparticle Imaging ProbesNanorodsPhotothermal EffectsPlasmonic Nanorods
In this paper, we demonstrate an application of a noninvasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time dependent. Finally, we determine the average concentration of GNRs within the whole SLN which is used to demonstrate uptake kinetics of the nanoparticles.
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Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
Sungjee Kim, Yong Taik Lim, Edward G. Soltesz et al. · Nature Biotechnology · 2003 · 2.1K citations