Aeruginosins 205A and -B, Serine Protease Inhibitory Glycopeptides from the Cyanobacterium <i>Oscillatoria agardhii</i> (NIES-205)

Abstract

Serine protease inhibitory glycopeptides, aeruginosins 205 A ( 1 ) and -B ( 2 ), were isolated from the cyanobacterium Oscillatoria agardhii (NIES-205). The gross structures of these glycopeptides were elucidated by mass and 2D NMR spectral data. The planar structure of 2 was the same as that of 1 but differed in the stereochemistries of 3-hydroxyleucine (Hleu) and phenyllactic acid 2- O -sulfate (Plas). These glycopeptides are potent inhibitors of trypsin and thrombin.