A Novel Synthesis of Isoflavones <i>via</i> Copper(I)‐Catalyzed Intramolecular Cyclization Reaction

Abstract

Abstract Isoflavone derivatives were synthesized via intramolecular cyclization of 3‐(2‐bromophenyl)‐3‐oxopropanal derivatives, using CuI as the catalyst, 2‐picolinic acid (=pyridine‐2‐carboxylic acid) as the ligand, K 2 CO 3 as the base, and DMF as the solvent, in up to 96% yield. The synthesis is functional group‐tolerant.