Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease - Concepedia

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Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease

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References

2006

Year

Abdelilah Laraqui, Abdellatif Allami, Alain Carrié, Sophie COIFFARD, F Benkouka, Abdelaziz Benjouad, Abdenabi Bendriss, Nizar El Kadiri, Nawal Bennouar, Anwar Benomar,

Acta Cardiologica

Abstract

Our data suggest that moderately elevated tHcy levels are prevalent in our population and are associated with an increased risk for CAD. This study provides evidence that the MTR A2756G and MTRR A66G polymorphisms significantly influence the circulating homocysteine concentration. In addition, the MTR and MTRR genes may interact to increase the risk for having hyperhomocysteinaemia.