Effect of Alcohol on miR‐212 Expression in Intestinal Epithelial Cells and Its Potential Role in Alcoholic Liver Disease

Abstract

These data suggest a novel mechanism for alcohol-induced gut leakiness, one in which EtOH induces miR-212 over-expression which causes gut leakiness by down-regulating ZO-1 translation. This mechanism is a potential therapeutic target for leaky gut in patients with or at risk for ALD.