Endothelin-1-Induced Pulmonary Vasoreactivity Is Regulated by ET<sub>A</sub> and ET<sub>B</sub> Receptor Interactions

Abstract

In rat lungs, both ET(A)-R and ET(B)-R contribute to ET-1-induced pulmonary vasoconstriction with evidence of interaction between receptors. A mild vasodilator role of the endothelial ET(B)-R is evident only at low agonist concentration and when baseline vascular tone is increased.