Glucose‐sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea‐pig.

TLDR

Afferent discharge recordings were obtained from dissected filaments of the guinea‑pig hepatic vagus branch in situ. A significant decrease in discharge rate occurred after portal‑vein D‑glucose injection but not after other sugars, and the mean discharge rate was inversely related to portal glucose concentration, indicating the presence of D‑glucose sensors in the liver. Other: No additional metadata provided.

Abstract

1. Afferent discharges were recorded from nerve filaments dissected from the hepatic branch of the vagus nerve in the guinea‐pig in situ. 2. A significant decrease in the discharge rate was observed following the administration of D‐glucose into the portal vein but not after the administration of D‐mannose, D‐fructose, D‐galactose, L‐glucose, D‐xylose or D‐arabinose. 3. The mean discharge rate of these fibres was inversely related to the concentration of glucose in the portal blood. 4. These results suggest the existence of D‐glucose ‘sensors’ in the liver which monitor the glucose concentration of portal blood.