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A Mild and Efficient Method for the Chemoselective Synthesis of Acylals from Aldehydes and their Deprotections Catalysed by Ceric Ammonium Nitrate
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2002
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Chemical EngineeringChemoselective SynthesisEngineeringCatalytic AmountEfficient MethodSustainable SynthesisOrganic ChemistryGeminal DiacetatesCatalysisStereoselective SynthesisChemistrySynthesis MethodCeric Ammonium NitrateAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisCatalytic SynthesisNatural Product Synthesis
A mild and efficient method has been developed for the chemoselective synthesis of geminal diacetates (acylals) from aldehydes using acetic anhydride in the presence of a catalytic amount of ceric ammonium nitrate in excellent yield. Ketones are found to be unaffected under the reaction conditions. The deprotections of acylals by using water and ceric ammonium nitrate have also been achieved.