Dietary orotic acid, a new selective growth stimulus for carcinogen altered hepatocytes in rat☆

New principle for the analysis of chemical carcinogenesis

Dennis B. Solt, Emmanuel Farber · Nature · 1976 · 788 citations

Medicine, Cancer Biology, Toxicology +14

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

Henry C. Pitot, Thomas L. Goldsworthy, Harold A. Campbell et al. · PubMed · 1980 · 373 citations

Pharmacy, Pharmacology, Toxicology +16

Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis.

Katsuhiro Ogawa, Dennis B. Solt, Emmanuel Farber · PubMed · 1980 · 201 citations

Medicine, Oncology, Pathology +17

Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.

Rolf Schulte‐Hermann, G. Ohde, J. Schuppler et al. · PubMed · 1981 · 193 citations

Medicine, Oncology, Pharmacology +15

Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures.

Amedeo Columbano, S. Rajalakshmi, D.S.R. Sarma · PubMed · 1981 · 186 citations

Medicine, Oncology, Toxicology +11