Solvent Microextraction into a Single Drop

TLDR

The study presents a low‑solvent, inexpensive technique that integrates solvent extraction with GC analysis. The method uses an 8 µL drop of organic solvent on a Teflon probe immersed in a stirred aqueous sample, then withdraws the probe, samples the drop with a microsyringe, and injects it into GC. Extraction kinetics agree with a convective‑diffusive model, and the method achieves a 1.7 % RSD for a 5‑min extraction of 4‑methylacetophenone into n‑octane.

Abstract

An analytical technique is described which combines solvent extraction with gas chromatographic (GC) analysis in a simple and inexpensive apparatus involving very little solvent consumption. A small drop (8 μL) of a water-immiscible organic solvent, containing an internal standard, is located at the end of a Teflon rod which is immersed in a stirred aqueous sample solution. After the solution has been stirred for a prescribed period of time, the probe is withdrawn from the aqueous solution, and the organic phase is sampled with a microsyringe and injected into the GC for quantification. The observed rate of solvent extraction is in good agreement with a convective−diffusive kinetic model. Analytically, the relative standard deviation of the method is 1.7% for a 5.00-min extraction of the analyte 4-methylacetophenone into n-octane.