Local Saline Infusion into Ischemic Territory Induces Regional Brain Cooling and Neuroprotection in Rats with Transient Middle Cerebral Artery Occlusion

Abstract

Local prereperfusion infusion effectively induced hypothermia and ameliorated brain injury from stroke. Clinically, this procedure could be used in acute stroke treatment, possibly in combination with intra-arterial thrombolysis or mechanical disruption of clot by means of a microcatheter.