A Case of Subacute Rickettsial Endocarditis; with a Survey of Cardiac Patients for this Infection

Abstract

FAMILYBDICALJOURL in the a-chain, and of haemoglobin S, which carries its abnormality in the a-chain into a-and P-chains.On recombination they obtained haemoglobin A as well as a hybrid composed of abnormal a-and ,8-chains.One might therefore expect that when haemoglobin S and another abnormal haemoglobin are found together with haemoglobin A, S being a al-chain mutant, the other abnormal haemoglobin would be an a-chain mutant.We have reason to believe, however, that haemoglobin 0 is not an a-chain mutant, and indeed the same applies to haemoglobin P. A full account of this will be given by two of us (B.R. and H.L.) in collaboration with Drs.E. M. Shooter and E. R. Huehns, of