Discorhabdin W, the First Dimeric Discorhabdin

Abstract

Discorhabdin W (1), isolated from a New Zealand Latrunculia sp. sponge, is a symmetrical dimer with potent in vitro activity against the P388 murine leukemia cell line. The structure and stereochemistry were assigned by using 1D- and 2D-NMR experiments and mass spectrometry. Discorhabdins B (2), D (3), G/I (4), and L (5) were also isolated from the same sponge.