Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers

Abstract

<b><i>Background/Aims:</i></b> There is emerging evidence of gabapentin and pregabalin (gabapentinoid) abuse, particularly in the substance misuse population, and some suggestion of gabapentinoids being abused alongside methadone. <b><i>Methods:</i></b> A questionnaire-based survey was carried out in six substance misuse clinics, looking for evidence of gabapentinoid abuse. <b><i>Results:</i></b> 22% (29/129) of respondents admitted to abusing gabapentinoids, and of these, 38% (11/29) abused gabapentinoids in order to potentiate the ‘high' they obtained from methadone. <b><i>Conclusions:</i></b> Gabapentinoid abuse along with methadone has not previously been described. These findings are of relevance to clinicians working within both substance misuse services and chronic pain services.