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Total synthesis of (±)-prostagladin D<sub>1</sub>: use of triethylsilyl protecting groups
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1979
Year
DerivativesBioorganic ChemistryBiochemistryEngineering-Prostaglandin D1Natural Sciences9-Triethylsilyl EtherTotal SynthesisOrganic ChemistryChemistry15-T-butyldimethylsilyl EtherPharmacologyDerivative (Chemistry)Synthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
(±)-Prostaglandin D1 has been synthesised by oxidation of (±)-PGF1α 15-t-butyldimethylsilyl ether and also of its 9-triethylsilyl ether; preparation and selective hydrolysis of triethylsilyl ethers are key steps in the sequence.