Micellar Catalysis of Suzuki−Miyaura Cross-Couplings with Heteroaromatics in Water

Abstract

Pd-catalyzed couplings involving several heteroaromatic halides (bromides and chlorides) as well as boronic acids can be done under exceedingly mild conditions (between rt and 40 degrees C) in pure water using commercially available Pd catalysts and PTS, a nanomicelle-forming amphiphile.