Critical Care Medicine · 1983 · 12 citations · 0 references
MedicineNeurologyPharmacologyNeonatologyNeuromuscular DisordersEclampsiaMagnesium DeficiencyMagnesium HomeostasisNeuromuscular BlockadeNeuromuscular Disorder PharmacotherapyNeuromuscular JunctionGentamicin TherapyNeuromuscular Junction TransmissionNeuromuscular Synaptic TransmissionNeuromuscular Transmission MonitoringPregnancy-related Magnesium Deficiency
A term neonate with hypermagnesemia secondary to maternal administration of MgSO4 for pre-eclampsia had a respiratory arrest after receiving gentamicin im. The neuromuscular tracings and sequential physician exams done before and after administering gentamicin suggest aminoglycosides may potentiate a magnesium-induced impairment of neuromuscular transmission and cause muscular weakness in neonates.