Total Synthesis of (−)‐Cleistenolide

Abstract

Abstract An efficient and short total synthesis of (−)‐cleistenolide ( 1 ) from D ‐mannitol with an overall yield of 23.6% is described. The chiron approach for the synthesis of (−)‐cleistenolide involves a one‐C‐atom Wittig olefination, a selective allylic triethylsilyl protection, and a Grubbs ‐catalyzed ring‐closure‐metathesis (RCM) reaction as the key steps.