Novel Isocyanide-Based Three-Component Synthesis of 3,4-Dihydroquinoxalin-2-amine Derivatives

Abstract

Synthesis of a novel class of highly substituted 3,4-dihydroquinoxalin-2-amine derivatives including spirocyclic compounds from three-component condensation reaction of o-phenylenediamines, diverse carbonyl compounds, and isocyanides in the presence of a catalytic amount of p-toluenesulfonic acid in good to excellent yields at room temperature is described.