Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation

The pathogenesis of cell death in Parkinson's disease

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Life Sciences, Neurology, Neuroscience +17

CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

Linsong Li, Cassian Yee, Joseph A. Beavo · Science · 1999 · 256 citations

Life Sciences, Biochemistry, Immunology +15

Convenient Method for the ortho-Formylation of Phenols.

Nini U. Hofsløkken, Lars Skattebøl, Fredrik Johansson et al. · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1999 · 201 citations · Full text

Natural Sciences, Chemistry, Organic Chemistry +2

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

Claudio Sette, Saveria Iona, Marco Conti · Journal of Biological Chemistry · 1994 · 181 citations · Full text

Life Sciences, Biochemistry, Endocrinology +15

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

Nikolaos Volakakis, Banafsheh Kadkhodaei, Eliza Joodmardi et al. · Proceedings of the National Academy of Sciences · 2010 · 164 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17