Bio-Based Solvent Mediated Synthesis of Dihydropyrimidinthiones Via Biginelli Reaction

Abstract

The three-component Biginelli reaction using aldehyde, thiourea, and 1,3-dicarbonyl compounds was performed smoothly in ethyl lactate (EL) with the catalysis of trimethylsilyl chloride (TMSCl). A class of 3,4-dihydropyrimidinthiones (DHPMs) were synthesized in good to excellent yields via the bio-based solvent mediated catalytic protocol.