Reduced Immobilizing Properties of Isoflurane and Nitrous Oxide in Mutant Mice Lacking the N-Methyl-d-Aspartate Receptor GluRε1 Subunit Are Caused by the Secondary Effects of Gene Knockout

Abstract

Our results confirm recent findings indicating no critical contribution of NMDA receptors to the immobility induced by isoflurane and nitrous oxide. In addition, they demonstrate the ability of changes secondary to genetic manipulation to affect the results obtained in global knockout studies.