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Bone Regeneration under the Influence of a Bone Morphogenetic Protein (BMP) Beta Tricalcium Phosphate (TCP) Composite in Skull Trephine Defects in Dogs
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References
1987
Year
Regenerative MedicineTissue EngineeringSkull Trephine DefectsDevelopmental BiologyEngineeringBeta Tricalcium PhosphateBone Morphogenic ProteinBone RepairBone RemodelingOsteoporosisBiomedical EngineeringBmp/tcp CompositeMedicineBmp/tcp ImplantsOrthopaedic SurgeryBone MetabolismOsteocalcinBone Morphogenetic Protein
Beta tricalcium phosphate (TCP) was employed as a nonimmunogenic biodegradable delivery system for bovine bone morphogenetic protein (BMP). A BMP/TCP composite was implanted in adult dogs with skull trephine defects of a critical size of 1.4 cm that would otherwise remain unhealed in the lifetime of the individual. BMP/TCP implants induced 91%-100% incorporation by deposits of new bone. In comparison, control implants of TCP impregnated with bovine serum albumin (BSA/TCP) induced 0%-8% incorporation, or only marginal host bed reactive bone formation. The retention of unabsorbed TCP in the host bone four months after implantation suggests that further research should be encouraged to obtain a formulation of sintered calcium phosphate that could be resorbed more rapidly and in the process more completely replaced by bone.