High-performance liquid chromatographic determination of mepyramine maleate, pheniramine maleate and phenylpropanolamine hydrochloride in tablets and drops

Abstract

HPLC with a chemically bonded β-cyclodextrin (Cyclobond I) column was used for the separation and determination of mepyramine maleate, pheniramine maleate and phenylpropanolamine hydrochloride in dosage forms. The intact compounds were separated and determined in standard mixtures and in selected pharmaceutical dosage forms. All three active ingredients in tablets and oral drops can be separated by HPLC; caffeine in timed-release tablets was determined by spectrophotometry after TLC separation from interfering components.