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Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole
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1975
Year
Bioorganic ChemistryAntiparasitic AgentAntitrypanosomal AgentsAntitrypanosomal PropertiesOrganic ChemistryChemical DerivativePharmaceutical ChemistryDrug ResistanceMedicinal ChemistryDerivativesBiochemistryAfrican TrypanosomiasisParasitic ProtozoaPharmacologyTrypanosoma RhodesienseNatural SciencesAntiparasitic NitroimidazolesMedicineDerivative (Chemistry)Drug Discovery
A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard reagent P), and dimethylaminoacetohydrazide (Girard reagent D) displayed good activity against Trypanosoma rhodesiense.