Sequential Rh(I)/Pd-Catalyzed 1,4-Addition/Intramolecular Allylation: Stereocontrolled Construction of γ-Butyrolactones and Cyclopropanes

Abstract

The rhodium-catalyzed conjugate addition of functionalized vinyltin reagents to alkylidene Meldrum's acids, followed by Pd-catalyzed intramolecular allylation, is a direct entry into vinyl-substituted gamma-lactones via O-alkylation and vinylcyclopropanes via C-alkylation.