¹⁸F-FDG Avidity of Pheochromocytomas and Paragangliomas: A New Molecular Imaging Signature?

Abstract

(18)F-FDG PET positivity is almost a constant feature of pheochromocytomas and paragangliomas. It may be considered a molecular signature of such tumors, although which aspect of the plethora of molecular changes associated with dedifferentiation, germline genetic defects, or the adaptive response to hypoxia is responsible for this characteristic requires further elucidation.