PROVOCATION OF CEREBRAL SEIZURES BY DERANGEMENT OF THE NATURAL BALANCE BETWEEN GLUTAMIC ACID AND γ‐AMINOBUTYRIC ACID

Abstract

SUMMARY After intracisternal injection of glutamic acid and pyridoxal 5‐phosphate, cerebral seizures could be evoked in dogs. With a small dose, these seizures were limited predominantly to the facial area. An interruption or prevention of the seizures was possible by intracistemal injection of γ‐aininobutyric acid or by pretreatment of the animals with α‐methyl‐α‐ethyl‐succinimide. The correspondence of clinical symptoms and therapeutic effect suggests a relation between these experimentally‐induced seizures and temporal lobe epilepsy in man.