Transplantation · 1973 · 18 citations · 0 references
Life SciencesImmunologySurgeryKidney TransplantationTransplant ImmunologyTransplant SurgeryAlloantigen RecognitionAllograft RejectionAntibody-mediated RejectionGraft SurvivalHistocompatibility AntigensTransplant RejectionDonor-recipient ImmunologyDonor-recipient PairingDonor-recipient RelationshipImmunologic Response To AllograftTransplant Immunogenicity
An experiment was performed to determine the relative uptake and loss of 125I-labeled transplantation alloantibody by long surviving enhanced, and recently transplanted nonenhanced kidney grafts. It was found that the two types of graft bind the same amount of specific antibody and subsequently release it at a similar rate. The results indicate that there is a dynamic state of antigen turnover by kidney allografts and that in this donor-recipient combination, long surviving enhanced kidney allografts have an undiminished number of free antigen sites. Experiments in vitro showed that radiolabeled antibody, combined with specific target cells, was also subsequently released. The characteristics of the cell-released radioactive material were examined