A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers

Abstract

We describe a facile synthesis of an <italic>n</italic>-butyl substituted choline phosphate monomer (MBP), and its polymerization to afford polyMBP and its copolymers. PolyMBP provides access to water-soluble choline phosphate polymers that by cell culture analysis exhibit low toxicity and immunogenicity.