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High throughput therapeutic drug monitoring of clozapine and metabolites in serum by on-line coupling of solid phase extraction with liquid chromatography–mass spectrometry

Liquid Chromatography–mass SpectrometryBiochemistrySolid Phase ExtractionMedicineDrug PurityBioanalysisMass SpectrometryOn-line CouplingDrug MonitoringAnalytical ChemistryLiquid ChromatographyClinical ChemistryChromatographic AnalysisPharmacologyPharmacokineticsChromatographyDrug Analysis