Dexamethasone Levels and Base-to-Apex Concentration Gradients in the Scala Tympani Perilymph After Intracochlear Delivery in the Guinea Pig

Abstract

With significantly higher, less variable drug levels and smaller base-to-apex concentration gradients, intracochlear applications have advantages to intratympanic injections. For further development of this technique, it is of importance to control leaks of perilymph and drug from the injection site and to evaluate its clinical feasibility and associated risks.