Influence of ACE-Inhibition and Mechanical Unloading on the Regulation of Extracellular Matrix Proteins in the Myocardium of Heart Transplantation Candidates Bridged by Ventricular Assist Devices

Abstract

Mechanical unloading by VAD does not reduce the collagen content of the terminal failing ventricle possibly due to increased TGF beta1 levels. However, Col1A1 production may be reduced by ACE-I medication during VAD support.