Efficacy and safety of two dosages of cotrimoxazole as preventive treatment for HIV‐infected Malawian adults with new smear‐positive tuberculosis

Abstract

CTX prophylaxis may have a beneficial effect on mortality and morbidity in HIV-infected smear-positive tuberculosis patients in Malawi. The efficacy of both dosages is not significantly different. The intervention is cheap and easy to implement. These results would support implementation of CTX in this patient group until better strategies are available or evidence is convincingly presented to suggest that its benefit is marginal.