Outpatient Treatment of <i>Pseudomonas aeruginosa</i> Bronchial Colonization with Long‐term Inhaled Colistin, Tobramycin, or Both in Adults without Cystic Fibrosis

Abstract

Results with colistin were similar to those with tobramycin for inhaled treatment of P. aeruginosa colonization in this population; however, combined use of colistin and tobramycin appeared to be associated with fewer days of hospitalization and shorter duration of antibiotic treatment. Prospective, double-blind, placebo-controlled trials of outpatient nebulized antibiotics, especially colistin plus tobramycin, should be performed to ascertain the efficacy of this therapy for treatment of P. aeruginosa colonization in patients without cystic fibrosis.